For more information on SDS and specification sheets, see the attached documents on our website. 


Description

GelXA LAMININK 411 is a bioink for applications with cells that require the presence of the laminin 411 isoform. Laminin is an extracellular matrix protein found predominantly within the basal lamina of many tissues. This protein is characterized by its cross-like structure that serves as a structural foundation for many tissues. It consists of three domains, known as alpha, beta, and gamma. Fifteen laminin trimers exist, with each combination serving different roles and cellular compatibility. Laminin 411 consists of a chain conformation of alpha4beta1gamma1 and is expressed in brain, muscle, and bone marrow. Largely produced by endothelial cells, laminin 411 has a pivotal role in endothelial basal laminae function and is present in various tissues during early development.


Application

GelXA LAMININK 411 can be applicable as a great starting point for the culture of many cell types. The laminin 411 composition is similar to the composition of many commercially available matrices derived from tumor extracts. This xenografic source allows better control over the matrix environment compared to other heterogenous matrices. This bioink supports the culture of various cell types, such as hematopoietic, vascular and immune cells. It may also be utilized as a base material for the development of pancreas models and the study of brain and nerve tissue. In pancreas, laminin 411 induces a cell signaling cascade in the β cells and in neural tissue, it is one of the major components of neural crest cell migration pathways.


See the attached document for the bioprinting protocol.