For more information on SDS and specification sheets, see the attached documents on our website.
GelXA LAMININK 121 is a bioink for applications with cells that require the presence of the laminin 121 isoform. Laminin is an extracellular matrix protein found predominantly within the basal lamina of many tissues. This protein is characterized by its cross-like structure that serves as a structural foundation for many tissues. It consists of three domains, known as alpha, beta, and gamma. Fifteen laminin trimers exist, with each combination serving different roles and cellular compatibility. Laminin 121 consists of a chain conformation of alpha1beta2gamma1 and is widely expressed during embryogenesis, important for early epithelial development and differentiation.
GelXA LAMININK 121 can be applicable as a great starting point for the culture of many cell types. The laminin 121 composition is similar to the composition of many commercially available matrices derived from tumor extracts. This xenografic source allows better control over the matrix environment compared to other heterogenous matrices. This bioink is particularly suitable as a material for the culture of cell types such as skeletal muscle, kidney, brain and liver cells.
See the attached document for the bioprinting protocol.