For more information on SDS and specification sheets, see the attached documents on our website.
Description
GelXA LAMININK 111 is a bioink for applications with cells that require the presence of the laminin 111 isoform. Laminin is an extracellular matrix protein found predominantly within the basal lamina of many tissues. This protein is characterized by its cross-like structure that serves as a structural foundation for many tissues. It consists of three domains, known as alpha, beta, and gamma. Fifteen laminin trimers exist, with each combination serving different roles and cellular compatibility. Laminin 111 consists of a chain conformation of alpha1beta1gamma1 and has been identified as a crucial molecule for embryogenesis and epithelial development. Laminin 111 is commonly used as a general attachment protein for most cell types in vitro.
Application
GelXA LAMININK 111 can be applicable as a great starting point for the culture of many cell types. The laminin 111 composition is similar to the composition of many commercially available matrices derived from tumor extracts. This xenografic source allows better control over the matrix environment compared to other heterogenous matrices. This bioink is suited for specialized applications that include the culture of liver, neural, lung, kidney and intestinal cells for the development of tissue models, and the culture of dopamine cells and cancer cells for the culture of disease states such as Parkinson’s disease and cancer models, respectively.
See the attached documents for the bioprinting protocol.