The system must be manually calibrated but some calibrations can be saved in the system. Instructions for saving the Z axis calibration can be found here: https://cellink.freshdesk.com/support/solutions/articles/35000105437-how-to-store-z-axis-calibration-on-the-ink-ink- 

Additionally, the offset between the 2 printheads can be saved. Follow these instructions to recalibrate this offset: https://cellink.freshdesk.com/support/solutions/articles/35000060910-how-to-calibrate-the-printhead-offset